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The Health Committees of the Canadian Manchester Terrier Club (CMTC) and American Manchester Terrier Club (AMTC) are asking for your help in dealing with serious heart problems affecting our breed.  MORE

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Canine Epilepsy Research at North Carolina State University <Request received Nov 7,2008>

To Whom it May Concern,

We are currently recruiting dogs for a research project which is looking for a genetic link to drug response in epileptic dogs. The project is being performed in the Department of Genetics and College of Veterinary Medicine at North Carolina State University. Much current research is designed to find out why some dogs get epilepsy. We're interested in a more practical question, namely why some dogs fail to respond to anti-epileptic drugs, specifically Phenobarbital. The idea is that there is variation among dogs and breeds in their ability to digest the drug, or deliver it to the right part of the brain, or maybe even in how the drug affects their neurons. This approach has already shown promise as a way to help doctors dose drug treatments for epilepsy in humans. We are going to adopt some of the technology from the Human Genome Project for use in dogs. To do so, we need to compare the DNA from blood samples from dogs that do or do not respond to Phenobarbital.

We already have several Manchester Terriers enrolled in our study and felt that this study may be of interest to other owners of epileptic Manchester Terriers. Can you please help us spread the word regarding our research by directing your members to our website: www.carolinacaninee pilepsy.org or they can email me directly at carolinacanineepile psy@gmail. com ?

Thank you for your time,

Erin Kennerly, Doctoral Candidate
NCSU – Dept. of Genetics; Dr. Greg Gibson's Lab
(919) 513-3090   E-Mail:  carolinacanineepilepsy@gmail.com
www.carolinacanineepilepsy.org

K9 Behavioral & Genetic Study

The Canine Behavioral Genetics Project is a collaboration between Dr. Steven Hamilton of the University of California, San Francisco and Dr. Karen Overall of the University of Pennsylvania.  Our project is currently recruiting participants and collecting DNA samples from both purebred and mixed-breed dogs.  Specifically, we are looking for:  1) To explore the relationship between genes and behavior, both normal and abnormal, in domestic dogs. 2) To assess the amount and nature of genetic diversity in domestic dogs, both within and between breeds. <more>

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